The effective alternative for erasing wrinkles and stimulating the dermal matrix.
 Matrixyl - How it works?

As we get older, the lack of collagen in the dermis is thought to be the major reason for wrinkle formation, so if the skin ca be stimulated into synthesising more collagen, we should be able to reverse the trend and diminish facial wrinkles. 

The active molecule in Matirxly is Micro-collagen, a peptide which, when applied to the skin surface via cream containing Matrixyl penetrates the skin, reaching the fibroblast cells.  Here it incites the cells to synthesis the molecules of connective tissue, the skin 'matrix', such as collagen and glycosaminoglycanes. 


 Why Micro-Collagen?

Matrixyl contains as the active ingredient a synthetic, miniature fragment of the skin's most abundant protein, collagen.  This fragment, a pentapeptide composed of the amino acids Lysine, Threonine and Serine, is made lipphilic by the attachment of palmitic acid to the first amino acid, which leads to the sequence Pal-Lys_Thr_Thr-Lys-Ser (Pal-KTTKS).

  Mimicking nature's tissue regenerating processes in which this fragment plays the role of messenger, Micro-collagen acts specifically on the cells of the dermis, signalling them to synthesis the material necessary for paddin gthe skin: connective tissue composed of proteins (collagen I, III, IV) and polysaccharides (glucosaminoglucanes, hyaluronic acid).

  In particular, collagen IV is important for the repair of the epidermal-dermal junction (EDJ) that maintains skin elasticity and profile.  The concept of "micro" is also reflected in the minute amounts of Micro-collagen needed to obtain cellular response: 3 ppm (mg per kg) suffice to activate the fibroblasts in the skin.  Thus, Micro-collagen;

  • is a synthetically obtained micro-fragment of natural collagen
  • initiates the stimulation of collagen synthesis
  • and is, therefore, able to replace collagen injection or other devices and methods in the treatment of wrinkles.

 Matrixyl - The evidence an industry first

In vitro and ex vivo studies show conclusively that Micro-collagen, the active ingredient of Matrixly, does induce cells to synthesise collagen and GAGs (glycosaminoglycanes).  Studies were then carried out on 35 volunteers over six month period - an industry first - with intermediate results analysed after two and four months.   The data confirmed that improvement of the skin is almost linear with time.

The same applies with self-assessment  - the percentage of volunteers who endorsed the statement "The product improves wrinkles", increases with time, paralled to the results of the physical measurements.

 Matrixyl - the new benchmark

A comparison study was carried out with Matrixyl cream against a commercial containing 5% Vitamin C, Vitamin C is currently used as the benchmark, by virtue of its own capability to stimulate collagen synthesis.  However, Vitamin C is difficult to formulate and stabilise in cosmetic formulas.

We have carried out a number of studies, all of which confirmed the indisputable efficacy of Matrixyl and the active ingredient Micro-Collagen:

  • in vitro on himan fibroflasts
  • ex vivo on human full thickness skin biopsies
  • in vivo on human volunteers over 2/4/6/ months.

Demonstration of the anti-wrinkle activity of Matrixyl compared to a marketed cream containing vitamin C.

Protocal: cream with 3% Matrixyl - Cream containing 5% Viamin C - 2 daily applications of each product during 6 months - 10 people - hermificial application.

Ther profilometric measurements are obtained from the analysis of the prints taken in the eye contour area.

1% of surface occupied with wrinkles (>200um)
2 Density of wrinkles
3 Roughness
4 Volume of the main wrinkle
5 Average depth of man wrinkle

The difference of the variations observed between the Matrixyl side and the vitamin C side is highly significant.

Matrixyl 3% = Blue
Vitamin C 5% = Orange

 Further tests

  in vitro

  Katayama et al (1991) investigated the stiumlating activity of the collagen fragment Lys-Thr-Lys-Ser on fibroblasts and found that this peptide inclreased the synthesis of collagen I and III, but also of Fibronectin, another matrix molecule of the connective tissue.

  We then studied the synthesis of glycosaminoglycanes (GAGs) in human skin fibroblasts and their stimulation by small amounts of Micro-collagen.  The rate of synthesis of GAGs is increased by 267% over the basic rate by 2% Matrixly.

  Ex vivo

  The repair effect of Micro-collagen on full thickness skin was proven in a biopsy model: the incorporation of the radiolabelled proline into collagen molecules was measured against the concentration of the peptide in comparison to Vitamin C and TGFB as controls.

  In vio

  Clinical examinations by a dermatologists confirmed the visual improvement of the wrinkles on the volunteers over the 2, 4, 6 month test period.



The wide range of tests carried out to study the cosmetic potential of the newly discovered protein fragment, Lys-Thr-Thr-Lys-Ser Micro-collagen leads to remarkable coherent results:

the biological activity of the active ingredient, manifest in all test protocols, substantiates our claim that Matrixyl with Micro-collagen contributes to the apprearance of the characteristics of a young, smooth skin.

Its anti-wrinkle activity is furthermore markedly superior to the current benchmark, Vitamin C, making it ideal for applications in a variety of areas including:

  • anti-aging products for face and body care
  • eye contour preparation
  • products for treating mature skin of face, neck and hands