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MATRIXYL |
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The effective alternative for
erasing wrinkles and stimulating the dermal matrix. |
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Matrixyl - How it works? |
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As we get older, the lack
of collagen in the dermis is thought to be
the major reason for wrinkle formation, so
if the skin ca be stimulated into
synthesising more collagen, we should be
able to reverse the trend and diminish
facial wrinkles.
The active molecule in
Matirxly is Micro-collagen, a peptide which,
when applied to the skin surface via cream
containing Matrixyl penetrates the skin,
reaching the fibroblast cells. Here it
incites the cells to synthesis the molecules
of connective tissue, the skin 'matrix',
such as collagen and glycosaminoglycanes.
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Why Micro-Collagen? |
Matrixyl contains as the
active ingredient a synthetic, miniature
fragment of the skin's most abundant
protein, collagen. This fragment, a
pentapeptide composed of the amino acids
Lysine, Threonine and Serine, is made
lipphilic by the attachment of palmitic acid
to the first amino acid, which leads to the
sequence Pal-Lys_Thr_Thr-Lys-Ser (Pal-KTTKS).
Mimicking nature's
tissue regenerating processes in which this
fragment plays the role of messenger,
Micro-collagen acts specifically on the
cells of the dermis, signalling them to
synthesis the material necessary for paddin
gthe skin: connective tissue composed of
proteins (collagen I, III, IV) and
polysaccharides (glucosaminoglucanes,
hyaluronic acid).
In particular,
collagen IV is important for the repair of
the epidermal-dermal junction (EDJ) that
maintains skin elasticity and profile.
The concept of "micro" is also reflected in
the minute amounts of Micro-collagen needed
to obtain cellular response: 3 ppm (mg per
kg) suffice to activate the fibroblasts in
the skin. Thus, Micro-collagen;
- is a
synthetically obtained micro-fragment of
natural collagen
- initiates the
stimulation of collagen synthesis
- and is,
therefore, able to replace collagen
injection or other devices and methods
in the treatment of wrinkles.
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Matrixyl - The evidence
an industry first |
In vitro and ex vivo
studies show conclusively that
Micro-collagen, the active ingredient of
Matrixly, does induce cells to synthesise
collagen and GAGs (glycosaminoglycanes).
Studies were then carried out on 35
volunteers over six month period - an
industry first - with intermediate results
analysed after two and four months.
The data confirmed that improvement of the
skin is almost linear with time.
The same applies with
self-assessment - the percentage of
volunteers who endorsed the statement "The
product improves wrinkles", increases with
time, paralled to the results of the
physical measurements. |
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Matrixyl - the new
benchmark |
A comparison study was
carried out with Matrixyl cream against a
commercial containing 5% Vitamin C, Vitamin
C is currently used as the benchmark, by
virtue of its own capability to stimulate
collagen synthesis. However, Vitamin C
is difficult to formulate and stabilise in
cosmetic formulas.
We have carried out a
number of studies, all of which confirmed
the indisputable efficacy of Matrixyl and
the active ingredient Micro-Collagen:
- in vitro on himan
fibroflasts
- ex vivo on human
full thickness skin biopsies
- in vivo on human
volunteers over 2/4/6/ months.
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Demonstration of the anti-wrinkle
activity of Matrixyl compared to a marketed cream
containing vitamin C.
Protocal: cream with 3% Matrixyl - Cream containing
5% Viamin C - 2 daily applications of each product
during 6 months - 10 people - hermificial
application.
Ther profilometric
measurements are obtained from the analysis of the
prints taken in the eye contour area.
1% of surface occupied with
wrinkles (>200um)
2 Density of wrinkles
3 Roughness
4 Volume of the main wrinkle
5 Average depth of man wrinkle
The difference of the
variations observed between the Matrixyl side and
the vitamin C side is highly significant.
Matrixyl 3% = Blue
Vitamin C 5% = Orange
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Further tests |
in vitro
Katayama et al (1991)
investigated the stiumlating activity of the
collagen fragment Lys-Thr-Lys-Ser on fibroblasts and
found that this peptide inclreased the synthesis of
collagen I and III, but also of Fibronectin, another
matrix molecule of the connective tissue.
We then studied the
synthesis of glycosaminoglycanes (GAGs) in human
skin fibroblasts and their stimulation by small
amounts of Micro-collagen. The rate of
synthesis of GAGs is increased by 267% over the
basic rate by 2% Matrixly.
Ex vivo
The repair effect of
Micro-collagen on full thickness skin was proven in
a biopsy model: the incorporation of the
radiolabelled proline into collagen molecules was
measured against the concentration of the peptide in
comparison to Vitamin C and TGFB as controls.
In vio
Clinical examinations
by a dermatologists confirmed the visual improvement
of the wrinkles on the volunteers over the 2, 4, 6
month test period.
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Conclusions |
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The wide range of tests
carried out to study the cosmetic potential
of the newly discovered protein fragment,
Lys-Thr-Thr-Lys-Ser Micro-collagen leads to
remarkable coherent results:
the biological activity
of the active ingredient, manifest in all
test protocols, substantiates our claim that
Matrixyl with Micro-collagen contributes to
the apprearance of the characteristics of a
young, smooth skin.
Its anti-wrinkle
activity is furthermore markedly superior to
the current benchmark, Vitamin C, making it
ideal for applications in a variety of areas
including:
- anti-aging
products for face and body care
- eye contour
preparation
- products for
treating mature skin of face, neck and
hands
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